abstract：:Previous studies have shown that excessive alcohol drinking is associated with chronic pain development; however, the molecular mechanism underlying this association is poorly understood. In this study, we investigated the effect of chronic alcohol consumption on plantar incision-induced postsurgical pain. We observed...

journal_title：Molecular neurobiology

authors： Liu S,Zhao Z,Guo Y,Shu H,Li C,Tang Y,Xing Y,Tao F

更新日期：2018-05-01 00:00:00

abstract：:The drastic increase in the consumption of fructose encouraged the research to focus on its effects on brain physio-pathology. Although young and adults differ largely by their metabolic and physiological profiles, most of the previous studies investigated brain disturbances induced by long-term fructose feeding in ad...

journal_title：Molecular neurobiology

authors： Cigliano L,Spagnuolo MS,Crescenzo R,Cancelliere R,Iannotta L,Mazzoli A,Liverini G,Iossa S

更新日期：2018-04-01 00:00:00

abstract：:NMDA receptor signaling is critical for the development of synaptic plasticity, learning, and memory, and dysregulation of NMDAR signaling is implicated in a number of neurological disorders including schizophrenia (SZ). Previous work has demonstrated that the STriatal-Enriched protein tyrosine Phosphatase 61 kDa (STE...

journal_title：Molecular neurobiology

authors： Xu J,Kurup P,Nairn AC,Lombroso PJ

更新日期：2018-04-01 00:00:00

abstract：:Tourette syndrome (TS) is a childhood-onset neurological disorder. To date, accurate TS diagnosis remains challenging due to its varied clinical expressions and dependency on qualitative description of symptoms. Therefore, identifying accurate and objective neuroimaging biomarkers may help improve early TS diagnosis. ...

journal_title：Molecular neurobiology

authors： Wen H,Liu Y,Rekik I,Wang S,Chen Z,Zhang J,Zhang Y,Peng Y,He H

更新日期：2018-04-01 00:00:00

abstract：:Parkinson's disease (PD) is characterized by the appearance of motor symptoms many years after the onset of neurodegeneration, which explains low efficiency of therapy. Therefore, one of the priorities in neurology is to develop an early diagnosis and preventive treatment of PD, based on knowledge of molecular mechani...

journal_title：Molecular neurobiology

authors： Mingazov ER,Khakimova GR,Kozina EA,Medvedev AE,Buneeva OA,Bazyan AS,Ugrumov MV

更新日期：2018-04-01 00:00:00

abstract：:We previously reported that fatty acid-binding protein 3 (FABP3) knockout (Fabp3 -/-) mice exhibit abnormal dopamine-related behaviors such as enhanced dopamine D2 receptor antagonist-induced catalepsy behaviors. Here, we report that Fabp3 null mice exhibit cognitive deficits, hyperlocomotion and impaired fear extinct...

journal_title：Molecular neurobiology

authors： Yabuki Y,Takahata I,Matsuo K,Owada Y,Fukunaga K

更新日期：2018-04-01 00:00:00

abstract：:Addiction is a chronic psychiatric disease which represents a global problem, and stress can increase drug addiction and relapse. Taking into account frequent concomitance of nicotine dependence and stress, the purpose of the present study was to assess behavioral and biochemical effects of chronic unpredictable mild ...

journal_title：Molecular neurobiology

authors： Biala G,Pekala K,Boguszewska-Czubara A,Michalak A,Kruk-Slomka M,Grot K,Budzynska B

更新日期：2018-04-01 00:00:00

abstract：:Metabolic defects are common pathological phenomena following traumatic brain injury (TBI) which contribute to poor prognosis. Brain-derived neurotrophic factor (BDNF) is an important regulator of neuronal survival, development, function, and plasticity. This study was designed to investigate the potential effects of ...

journal_title：Molecular neurobiology

authors： Xu Z,Lv XA,Dai Q,Lu M,Jin Z

更新日期：2018-04-01 00:00:00

abstract：:Neuroblastoma (NB) is an extracranial solid cancer and the most common cancer in infancy. Despite the standard treatment for NB is based on the combination of chemotherapeutic drugs such as doxorubicin, vincristine, cyclophosphamide, and cisplatin, chemoresistance occurs over the time. The aim of the present research ...

journal_title：Molecular neurobiology

authors： Tibullo D,Giallongo C,Puglisi F,Tomassoni D,Camiolo G,Cristaldi M,Brundo MV,Anfuso CD,Lupo G,Stampone T,Li Volti G,Amenta F,Avola R,Bramanti V

更新日期：2018-04-01 00:00:00

abstract：:Brain injuries such as trauma and stroke lead to glial scar formation by reactive astrocytes which produce and secret axonal outgrowth inhibitors. Chondroitin sulfate proteoglycans (CSPG) constitute a well-known class of extracellular matrix molecules produced at the glial scar and cause growth cone collapse. The CSPG...

journal_title：Molecular neurobiology

authors： Galindo LT,Mundim MTVV,Pinto AS,Chiarantin GMD,Almeida MES,Lamers ML,Horwitz AR,Santos MF,Porcionatto M

更新日期：2018-04-01 00:00:00

abstract：:Maternal folate status during pregnancy may influence central nervous system (CNS) development in offspring. However, the recommended intakes of folic acid for women of childbearing age differ among countries and there is still no consensus about whether folic acid should be supplemented continuously throughout pregna...

journal_title：Molecular neurobiology

authors： Wang X,Li W,Li S,Yan J,Wilson JX,Huang G

更新日期：2018-03-01 00:00:00

abstract：:Presenilin 1 (PS1) is a catalytic component of the γ-secretase complex, responsible for the intramembraneous cleavage of more than 90 type I transmembrane proteins, including Alzheimer's disease (AD)-related amyloid precursor protein (APP). The γ-secretase-mediated cleavage of the APP C-terminal membrane stub leads to...

journal_title：Molecular neurobiology

authors： Zoltowska KM,Berezovska O

更新日期：2018-03-01 00:00:00

abstract：:Following stroke, complete cellular death in the ischemic brain area may ensue, with remaining brain areas undergoing tissue remodelling to various degrees. Experience-dependent brain plasticity exerted through an enriched environment (EE) promotes remodelling after central nervous system injury, such as stroke. Post-...

journal_title：Molecular neurobiology

authors： Quattromani MJ,Pruvost M,Guerreiro C,Backlund F,Englund E,Aspberg A,Jaworski T,Hakon J,Ruscher K,Kaczmarek L,Vivien D,Wieloch T

更新日期：2018-03-01 00:00:00

abstract：:Cognitive control processes play an essential role not only in controlling actions but also in guiding attentional selection processes. Interestingly, these processes are strongly affected by organizational principles of the cerebral cortex and related functional asymmetries, but the neurobiological foundations are el...

journal_title：Molecular neurobiology

authors： Beste C,Arning L,Gerding WM,Epplen JT,Mertins A,Röder MC,Bless JJ,Hugdahl K,Westerhausen R,Güntürkün O,Ocklenburg S

更新日期：2018-03-01 00:00:00

abstract：:The limited capacity for the central nervous system (CNS) to repair itself was first described over 100 years ago by Spanish neuroscientist Ramon Y. Cajal. However, the exact mechanisms underlying this failure in neuronal regeneration remain unclear and, as such, no effective therapeutics yet exist. Numerous studies h...

journal_title：Molecular neurobiology

authors： Boghdadi AG,Teo L,Bourne JA

更新日期：2018-03-01 00:00:00

abstract：:Occurrence of stroke cases displays a time-of-day variation in human. However, the mechanism linking circadian rhythm to the internal response mechanisms against pathophysiological events after ischemic stroke remained largely unknown. To this end, temporal changes in the susceptibility to ischemia/reperfusion (I/R) i...

journal_title：Molecular neurobiology

authors： Beker MC,Caglayan B,Yalcin E,Caglayan AB,Turkseven S,Gurel B,Kelestemur T,Sertel E,Sahin Z,Kutlu S,Kilic U,Baykal AT,Kilic E

更新日期：2018-03-01 00:00:00

abstract：:Melanocortins are peptides with well-recognized antiinflammatory and neuroprotective activity. No data are currently available on melanocortin receptor-4 (MC4R) gene polymorphisms and tumors, including glioblastomas (GBMs), or their relationship with radiotherapy or chemotherapy. The aim of this study was to evaluate ...

journal_title：Molecular neurobiology

authors： Pasqualetti F,Orlandi P,Simeon V,Cantarella M,Giuliani D,Di Desidero T,Gonnelli A,Delishaj D,Lombardi G,Sechi A,Sanson M,Zagonel V,Paiar F,Danesi R,Guarini S,Bocci G

更新日期：2018-02-01 00:00:00

abstract：:Long-lasting changes in dendritic spines provide a physical correlate for memory formation and persistence. LIM kinase (LIMK) plays a critical role in orchestrating dendritic actin dynamics during memory processing, since it is the convergent downstream target of both the Rac1/PAK and RhoA/ROCK pathways that in turn i...

journal_title：Molecular neurobiology

authors： Lunardi P,Sachser RM,Sierra RO,Pedraza LK,Medina C,de la Fuente V,Romano A,Quillfeldt JA,de Oliveira Alvares L

更新日期：2018-02-01 00:00:00

abstract：:The role of matrix metalloproteinase-12 (MMP-12) in the pathogenesis of several inflammatory diseases such as chronic obstructive pulmonary disease, emphysema, and asthma is well established. Several new studies and recent reports from our laboratory and others highlighted the detrimental role of MMP-12 in the pathoge...

journal_title：Molecular neurobiology

authors： Chelluboina B,Nalamolu KR,Klopfenstein JD,Pinson DM,Wang DZ,Vemuganti R,Veeravalli KK

更新日期：2018-02-01 00:00:00

abstract：:Ryanodine receptors (RyRs) are intracellular calcium-release channels found on the endoplasmic reticulum of all cells. All three RyR isoforms, RyR1-3, are expressed in the brain, with RyR2 predominating. RyRs are localized within the soma, axons, dendritic spines, and presynaptic terminals of neurons. RyRs are highly ...

journal_title：Molecular neurobiology

authors： Abu-Omar N,Das J,Szeto V,Feng ZP

更新日期：2018-02-01 00:00:00

abstract：:Clinical studies demonstrated a positive correlation between hypertension and cognitive decline. Beneficial effects of angiotensin II receptor blockers on cognitive functions have also been reported earlier; however, its role in chronic neuroinflammation-induced memory impairment in the hypertensive state is not well ...

journal_title：Molecular neurobiology

authors： Goel R,Bhat SA,Hanif K,Nath C,Shukla R

更新日期：2018-02-01 00:00:00

abstract：:Docosahexaenoic acid (DHA) is enriched in membrane phospholipids of the central nervous system (CNS) and has a role in aging and neuropsychiatric disorders. DHA is metabolized by the enzyme Alox15 to 17S-hydroxy-DHA, which is then converted to 7S-hydroperoxy,17S-hydroxy-DHA by a 5-lipoxygenase, and thence via epoxy in...

journal_title：Molecular neurobiology

authors： Shalini SM,Ho CF,Ng YK,Tong JX,Ong ES,Herr DR,Dawe GS,Ong WY

更新日期：2018-02-01 00:00:00

abstract：:Inhalational general anesthetics, such as sevoflurane and isoflurane, modulate a subset of brain Kv1 potassium channels. However, the Kv1.2 channel is resistant to propofol, a commonly used intravenous alkylphenol anesthetic. We hypothesize that propofol binds to a presumed pocket involving the channel's S4-S5 linker,...

journal_title：Molecular neurobiology

authors： Bu W,Liang Q,Zhi L,Maciunas L,Loll PJ,Eckenhoff RG,Covarrubias M

更新日期：2018-02-01 00:00:00

abstract：:Soluble epoxide hydrolase (sEH) is widely expressed in the mammalian brain and possesses dual enzymatic activities, including C-terminal epoxide hydrolase (C-EH) which degrades epoxyeicosatrienoic acid (EET), a beneficial arachidonic acid metabolite. In the present study, the neuroprotective effect of sEH inhibition o...

journal_title：Molecular neurobiology

authors： Huang HJ,Wang YT,Lin HC,Lee YH,Lin AM

更新日期：2018-01-01 00:00:00

abstract：:The present investigation is an expansion of previous studies which all share a basic experimental protocol of a porcine-induced cardiac arrest (CA) of 12 min followed by 8 min of cardiopulmonary resuscitation (CPR), different experimental treatments (immediate as well as postponed induced mild hypothermia and adminis...

journal_title：Molecular neurobiology

authors： Wiklund L,Patnaik R,Sharma A,Miclescu A,Sharma HS

更新日期：2018-01-01 00:00:00

abstract：:Neurotrophic factors are essential for neuronal survival, plasticity, and development and have been implicated in the action mechanism of antidepressants. In this study, we assessed the neurotrophic factor-inducing and neuroprotective properties of antidepressants. In the first part of the study, we found that fluoxet...

journal_title：Molecular neurobiology

authors： Shadfar S,Kim YG,Katila N,Neupane S,Ojha U,Bhurtel S,Srivastav S,Jeong GS,Park PH,Hong JT,Choi DY

更新日期：2018-01-01 00:00:00

abstract：:Inflammation plays a crucial role in the pathogenesis of stroke. This study aims to determine lipoprotein (a) [Lp(a)] levels in serum and to investigate their associations with stroke recurrence events in a 3-month follow-up study in patients with acute ischemic stroke (AIS). Serum Lp(a) levels were determined in 203 ...

journal_title：Molecular neurobiology

authors： Hong XW,Wu DM,Lu J,Zheng YL,Tu WJ,Yan J

更新日期：2018-01-01 00:00:00

abstract：:Dendritic spines, a special kind of structure in nerve cells, play a key role in performing cellular function. Structural abnormalities of the dendritic spine may contribute to synaptic dysfunction and have been implicated in memory formation. However, the molecular mechanisms that trigger dendritic spine loss remain ...

journal_title：Molecular neurobiology

authors： Liu Q,Feng R,Chen Y,Luo G,Yan H,Chen L,Lin R,Ding Y,Wen T

更新日期：2018-01-01 00:00:00

abstract：:Previous studies have demonstrated depressive or hibernation-like roles of phenothiazine neuroleptics [combined chlorpromazine and promethazine (C + P)] in brain activity. This ischemic stroke study aimed to establish neuroprotection by reducing oxidative stress and improving brain metabolism with post-ischemic C + P ...

journal_title：Molecular neurobiology

authors： Geng X,Li F,Yip J,Peng C,Elmadhoun O,Shen J,Ji X,Ding Y

更新日期：2017-12-01 00:00:00

abstract：:Establishing systemic therapeutics for neuro-inflammatory diseases is a main objective of regenerative medicine, certainly focusing on restoration of BBB dysfunction and neurovascular reconstitution. In this context, the regenerative capacity and therapeutic effects of different stem cells have been recently found to ...

journal_title：Molecular neurobiology

authors： Geranmayeh MH,Nourazarian A,Avci ÇB,Rahbarghazi R,Farhoudi M

更新日期：2017-12-01 00:00:00

abstract：:Paclitaxel is a chemotherapeutic agent used to treat solid tumours. However, it causes an acute and neuropathic pain syndrome that limits its use. Among the mechanisms involved in neuropathic pain caused by paclitaxel is activation of kinin receptors. Angiotensin converting enzyme (ACE) inhibitors can enhance kinin re...

journal_title：Molecular neurobiology

authors： Brusco I,Silva CR,Trevisan G,de Campos Velho Gewehr C,Rigo FK,La Rocca Tamiozzo L,Rossato MF,Tonello R,Dalmolin GD,de Almeida Cabrini D,Gomez MV,Ferreira J,Oliveira SM

更新日期：2017-12-01 00:00:00

abstract：:Multiple sclerosis (MS) is an autoimmune, inflammatory disease of the central nervous system (CNS). We have measured the levels of over 20 non-esterified sterols in plasma and cerebrospinal fluid (CSF) from patients suffering from MS, inflammatory CNS disease, neurodegenerative disease and control patients. Analysis w...

journal_title：Molecular neurobiology

authors： Crick PJ,Griffiths WJ,Zhang J,Beibel M,Abdel-Khalik J,Kuhle J,Sailer AW,Wang Y

更新日期：2017-12-01 00:00:00

abstract：:Parkinson's disease and other synucleinopathies are characterized by the presence of intra-neuronal protein aggregates enriched in the presynaptic protein α-synuclein. α-synuclein is considered an intrinsically disordered 14 kDa monomer, and although poorly understood, its transition to higher-order multimeric species...

journal_title：Molecular neurobiology

authors： Abdullah R,Patil KS,Rosen B,Pal R,Prabhudesai S,Lee S,Basak I,Hoedt E,Yang P,Panick K,Ho HP,Chang E,Tzoulis C,Larsen JP,Neubert TA,Alves G,Møller SG

更新日期：2017-12-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease manifested by the progressive loss of upper and lower motoneurons. The pathomechanism of ALS is complex and not yet fully understood. Neuroinflammation is believed to significantly contribute to disease progression. Inflammasome activation was re...

journal_title：Molecular neurobiology

authors： Heitzer M,Kaiser S,Kanagaratnam M,Zendedel A,Hartmann P,Beyer C,Johann S

更新日期：2017-12-01 00:00:00

abstract：:Five-prime repressor element under dual repression binding protein-1 (Freud-1)/CC2D1A is genetically linked to intellectual disability and implicated in neuronal development. Freud-1 represses the serotonin-1A (5-HT1A) receptor gene HTR1A by histone deacetylase (HDAC)-dependent or HDAC-independent mechanisms in 5-HT1A...

journal_title：Molecular neurobiology

authors： Souslova T,Mirédin K,Millar AM,Albert PR

更新日期：2017-12-01 00:00:00

abstract：:Depletion of oxygen and glucose even for brief periods is sufficient to cause cerebral ischemia, which is a predominant worldwide cause of motor deficits with the reduction of life quality and subsequently death. Hence, more insights regarding protective measures against ischemic events are becoming a major research g...

journal_title：Molecular neurobiology

authors： Mele M,Morelli S,Fazzari G,Avolio E,Alò R,Piscioneri A,De Bartolo L,Facciolo RM,Canonaco M

更新日期：2017-11-01 00:00:00

abstract：:Cerebral ischemia is a cerebrovascular episode that generates a high incidence of death and physical and mental disabilities worldwide. Excitotoxicity, release of free radicals, and exacerbated immune response cause serious complications in motor and cognitive areas during both short and long time frames post-ischemia...

journal_title：Molecular neurobiology

authors： Becerra-Calixto A,Cardona-Gómez GP

更新日期：2017-11-01 00:00:00

abstract：:This work was aimed at investigating the circulating microRNA (miRNA) profiles in serum and saliva of patients affected by fibromyalgia syndrome (FM), correlating their expression values with clinical and clinimetric parameters and to suggest a mathematical model for the diagnosis of FM. A number of 14 FM patients and...

journal_title：Molecular neurobiology

authors： Masotti A,Baldassarre A,Guzzo MP,Iannuccelli C,Barbato C,Di Franco M

更新日期：2017-11-01 00:00:00

abstract：:Sirtuin 2 (SIRT2) is a member of NAD+-dependent protein deacetylases involved in a wide range of pathophysiological processes including myocardial injury, Parkinson's disease, and Huntington's disease. However, the direct implication of SIRT2 in ischemic stroke is still unclear. In the present study, we observed that ...

journal_title：Molecular neurobiology

authors： Xie XQ,Zhang P,Tian B,Chen XQ

更新日期：2017-11-01 00:00:00

abstract：:Activation of RhoA/Rho kinase leads to growth cone collapse and neurite retraction. Although RhoA/Rho kinase inhibition has been shown to improve axon regeneration, remyelination and functional recovery, its role in neuronal cell death remains unclear. To determine whether RhoA/Rho kinase played a role in neuronal dea...

journal_title：Molecular neurobiology

authors： Wu X,Walker CL,Lu Q,Wu W,Eddelman DB,Parish JM,Xu XM

更新日期：2017-11-01 00:00:00